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Proficient Technology: |
 Chiral resolution |
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Asymmetric synthesis |
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Oxidizing and reducing reactions |
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Amination |
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Esterification |
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Catalyzing hydrogenation |
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C, O, N-Alkylation |
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Heterocyclic synthesis |
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Examples:
Resolution: developing new methods of chemical resolution, crystal engineering.
"Combi natorial Approach" for the Choice of Resolving Reagents and Resolution of Chiral Drugs: |
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(R)-Albuterol with D-DBTA |
(>R)-Terbutaline with D-DTTA |
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Patent: ZL 01 1 07380.2, ZL 99 1 17313.9.
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Asymmetric synthesis: designing new chiral ligands and developing new asymmetric reactions. |
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Asymmetric Transfer Hydrogenation in Water |
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J. Org. Chem.2005, 70, 9424-9429; Org. Lett.2003, 5, 2103.
Patent: ZL 03135181.6
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New drug development:integrating chirotechnologies methodologies to develop new drugs. |
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Patent: ZL 98 1 24029.1, ZL 03 1 35146.6.
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